La activity antihepatotoxic of the milk thistle fruit and the silymarin It has been known for many years. Its positive effect on liver is based on actions antirust, membrane stabilizer, promoter of protein synthesis, antiviral, anti-inflammatory, immunomodulatory and anticholestatic of silymarin and its main component, silibinin. 

In addition to activity antihepatotoxic, The clinical efficacy of Milk Thistle has been demonstrated in different types of liver disorders, mainly in those produced by alcohol and those caused by viruses. Several studies have established the chemopreventive role full silymarin and of silibinin in different cancer cell lines, as well as its stimulating effect on milk secretion, in addition to its action in other areas (bone protection, neuroprotection, atherogenesis, etc.). To this set of data, which point to possible new applications of the products obtained from the milk thistle, is added its wide therapeutic margin and its low toxicity. 

Phytotherapy Magazine 2012; 12(2):101-116

What is antihepatotoxic activity

Antihepatotoxic activity refers to the ability of a substance or compound to protect the liver and prevent or reverse liver damage. The liver is a vital organ that performs numerous functions in the body, including detoxification of harmful substances, protein synthesis, and bile production for fat digestion.

Various factors, such as excessive alcohol consumption, the use of certain medications, exposure to toxins, or liver disease, can cause liver damage. The antihepatotoxic activity is focused on protecting this organ and promoting its health.

Some naturally occurring substances, such as certain herbal medicines and antioxidants, have been studied for their antihepatotoxic activity. These substances may have protective effects by reducing cellular oxidation, decreasing inflammation, enhancing liver cell regeneration, and promoting the removal of toxins from the liver.